 |
Antidepressants for CFS*
|
AGENT |
ACTIVATION
|
NEURO
TRANS |
SEX
DYSF |
ANTI-
CHOL |
DEEP
SLEEP |
REM
LAT |
REM
LGTH |
CYP
INHIB |
INDIC |
NMH |
SD
DOSE |
|
Wellbutrin
(bupropion) |
+++ |
D, NE |
0 |
0 |
- |
0 |
+ |
0 |
DEP |
ND |
100-150mg |
|
Prozac
(fluoxetine) |
+++ |
S |
+++ |
0 |
- - |
+ |
- |
+++ |
DEP,
OCD |
+ |
10-20mg |
|
Zoloft
(sertraline) |
++ |
S |
++ |
0 |
- |
+ |
- |
++ |
DEP,
PD, OCD |
+ |
50-100mg |
|
Celexa
(citalopram) |
+ |
S |
+ |
0 |
- |
+ |
- |
0 |
DEP |
ND |
10-20mg |
|
Paxil
(paroxetine) |
+ |
S |
++ |
± |
- |
+ |
= |
+++
(2D6 only) |
DEP,OCD,PD, SD |
+ |
10-20mg |
|
Effexor(venlafaxine) |
+ |
S, NE |
+ |
0 |
- |
+ |
- |
0 |
DEP,GAD |
ND |
37.5mg |
|
Elavil(amitriptyline) |
- |
S, NE |
ND |
++ |
- |
+ |
- |
0 |
DEP |
NO |
10-50mg |
|
Desyrel(trazadone) |
- |
S |
0 |
± |
++ |
- |
- |
0 |
DEP |
ND |
50-100mg |
|
Remeron(mirtazapine) |
-
- |
S,A2, H |
0 |
0 |
+ |
+ |
- |
0 |
DEP |
ND |
7.5
(for sleep) – 30mg (to increase energy) |
|
Serzone(nefazadone) |
-
- |
S, NE |
0 |
0 |
± |
- |
+ |
+++
(3A4 only) |
DEP |
ND |
25-50mg |
*Author’s note: This chart is
intended only to give a representative sampling of different drugs commonly used
to treat CFS patients. It is not all-inclusive.
ACTIVATION Effect
on patient’s energy levels
NEUROTRANS
Neurotransmitters involved: D=dopamine, NE =
norepinephrine, S = serotonin, a2 =
alpha receptors, H = histamine receptors
SEX
DYSF Level
of sexual dysfunction that occurs as side effect
ANTI-CHOL Anticholinergic
effect of drug
DEEP
SLEEP
Effect of depth of sleep (stages 3 and 4)
REM
LAT REM
latency, the time to onset of REM (typically 90 minutes)
REM
LGTH REM
length, the amount of time spent in REM sleep
CYP
INHIB Level
of cytochrome P450 enzyme (1 A2, 2C, 2D6, 3A4) inhibition
INDIC
FDA indicated for: DEP = depression, OCD =
obsessive-compulsive disorder, PD = panic disorder,
SD = social anxiety disorder, GAD = general anxiety disorder
NMH Effect
on neurally mediated hypotension
SD
DOSE Starting
daily dose
+ =
increased; 0 = no change; - = decreased; ND = no data
available
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