NMH and OI* in Children and Adolescents

Medical Journal Articles

* NMH=Neurally Mediated Hypotension, OI=Orthostatic Intolerance

Following is a list of articles about neurally mediated hypotension and orthostatic intolerance in youth that have been published in the peer-reviewed medical literature. If we have been able to locate the article's abstract on line, we have provided a link to that abstract. If you wish to read an article that does not have a link, please contact your local medical library or hospital.

Most of these articles focus on children and adolescents. To read articles about research in adults, do a search on PubMed, the search engine of the National Library of Medicine.

Review Articles and Introductory Materials

• General Information Brochure on Neurally Mediated Hypotension and its Treatment Neurally Mediated Hypotension Working Group, Johns Hopkins Hospital
  
  
• Grubb BP: Cerebral syncope: New insights into an emerging entity. J Peds 2000 April;136(4):431-432.
  
  
• Saul JP: Syncope: etiology, management, and when to refer. J S C Med Assoc 1999 Oct;95(10):385-7.
  
  

Neurally Mediated Hypotension

• Tanaka H, Matsushima R, Tamai H, Kajimoto Y:  Impaired postural cerebral hemodynamics in young patients with chronic fatigue with and without orthostatic intolerance.  J Pediatr. 2002 Apr;140(4):412-7.
  
  
• Rowe PC:  Orthostatic intolerance and chronic fatigue syndrome: New light on an old problem.  J Pediatr. 2002 Apr;140(4):387-9.
  
  
• Stewart JM:  Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects.  Circulation. 2002 May 14;105(19):2274-81.
  
  
• Stewart JM:  Orthostatic intolerance in pediatrics.  J Pediatr. 2002 Apr;140(4):404-11. No abstract available.
  
  
• Stewart JM.:  Orthostatic hypotension in pediatrics.  Heart Dis. 2002 Jan-Feb;4(1):33-9. Review.
   
  
• Stewart JM, Weldon A: Inappropriate Early Hypotension in Adolescents: A Form of Chronic Orthostatic Intolerance with Defective Dependent Vasoconstriction. Pediatr Res. 2001 Jul;50(1):97-103.
  
  
• Stewart JM, Weldon A: The relation between lower limb pooling and blood flow during orthostasis in the postural orthostatic tachycardia syndrome of adolescents. J Pediatr 2001;138:512-9.
  
  
• Stewart JM, Weldon A: Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. J Appl Physiol 2000 Oct;89(4):1505-1512.
  
  
• Tanaka H, Yamaguchi H, Matushima R, Tamai H: Instantaneous orthostatic hypotension in children and adolescents: a new entity of orthostatic intolerance. Pediatr Res. 1999 Dec;46(6):691-6.
  
  
• Massin MM, Leroy P: A 9-year-old girl with chronic fatigue. Diagnosis: neurally mediated hypotension. Eur J Pediatr 1999 Sep;158(9):761-2.
  
  
• Rowe PC, Calkins H: Neurally mediated hypotension and chronic fatigue syndrome. Am J Med 1998 Sep 28;105(3A):15S-21S.
  
  
• Rowe PC, et al: Is neurally mediated hypotension an unrecognized cause of chronic fatigue? Lancet. 1995 Mar 11;345(8950):623-4.
  
  
• Bou-Holaigah I, Rowe PC, Kan J, Calkins H: The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA 1995 September 27; 274(12): 961-967.
  
  

Postural Orthostatic Tachycardia Syndrome

• Stewart JM:  Transient orthostatic hypotension is common in adolescents.  J Pediatr. 2002 Apr;140(4):418-24.
  
  
• Stewart JM, Weldon A: Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. J Appl Physiol 2000 Oct;89(4):1505-1512.
  
  
• Stewart JM: Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res. 2000 Aug;48(2):218-26.
  
  
• Karas B, Grubb BP, Boehm K, Kip K: The postural orthostatic tachycardia syndrome: a potentially treatable cause of chronic fatigue, exercise intolerance, and cognitive impairment in adolescents. Pacing Clin Electrophysiol 2000 Mar;23(3):344-51.
  
  
• Stewart JM, Gewitz MH, Weldon A, Munoz J: Patterns of orthostatic intolerance: the orthostatic tachycardia syndrome and adolescent chronic fatigue. J Pediatr 1999 Aug;135(2 Pt 1):218-25. Review.
  
  
• Stewart JM, Gewitz MH, Weldon A, Arlievsky N, Li K, and Munoz J: Orthostatic Intolerance in Adolescent Chronic Fatigue Syndrome. Pediatrics. 1999 January; 103(1): 116-121.
  
  
• Stewart JM, et al: Neurally mediated hypotension and autonomic dysfunction measured by heartrate variability during head-up tilt testing in children with chronic fatigue syndrome. Clin Auton Res . 1998 Aug;8(4):221-30.
  
  

Cerebral Blood Flow and Syncope

• Grubb BP: Cerebral syncope: New insights into an emerging entity. J Peds 2000 April;136(4):431-432.
  
  
• Tomoda A, Miike T, Yamada E, Honda H, Moroi T, Ogawa M, Ohtani Y, Morishita S: Chronic fatigue syndrome in childhood. Brain Dev . 2000 Jan;22(1):60-4.
  
  
• Rodríguez-Núñez A, Fernández-Cebrián S, Pérez-Muñuzuri A, Martinón-Torres F, Eirís-Puñal J, Martinón-Sánchez JM: Cerebral syncope in children J Peds 2000 April;136(4).
  
  
• Sung RYT, Du ZD, Yu CW, Yam MC, and Fok TF: Cerebral blood flow during vasovagal syncope induced by active standing or head up tilt. Arch. Dis. Child . 2000;82 154-158.
  
  
• Rodriguez RA, Snider K, Cornel G, Teixeira OH: Cerebral blood flow velocity during tilt table test for pediatric syncope.Pediatrics 1999 Aug;104(2 Pt 1):237-42. Review.
  
  

Autonomic Dysfunction

• Stewart JM: Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res . 2000 Aug;48(2):218-26.
  
  
• Burklow TR, Moak JP, Bailey JJ, Makhlouf FT: Neurally mediated cardiac syncope: autonomic modulation after normal saline infusion. J Am Coll Cardiol 1999 Jun;33(7):2059-66. Review.
  
  
• Stewart JM, et al: Neurally mediated hypotension and autonomic dysfunction measured by heartrate variability during head-up tilt testing in children with chronic fatigue syndrome. Clin Auton Res . 1998 Aug;8(4):221-30.
  

Neuroendocrinology

• Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ: Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome. J Clin Endocrinol Metab 2000 Feb;85(2):692-6.
  
  

Nephrology

• Takahashi Y, Ohta S, Sano A, Kuroda Y, Kaji Y, Matsuki M, Matsuo M: Does severe nutcracker phenomenon cause pediatric chronic fatigue? Clin Nephrol 2000 Mar;53(3):174-81.
  
  
• Takahashi Y, Sano A, Matsuo M: An effective "transluminal balloon angioplasty" therapy for pediatric chronic fatigue syndrome with nutcracker phenomenon. Clin Nephrol . 2000 Jan;53(1):77-8. No abstract available. PMID: 10661488; UI: 20125130.
  
  

Fibomyalgia and Orthostatic Intolerance

• Rusy LM, Harvey SA, Beste DJ: Pediatric fibromyalgia and dizziness: evaluation of vestibular function.  J Dev Behav Pediatr 1999 Aug;20(4):211-5. Review.
  
  
• Bou-Holaigah I, Calkins H, Flynn JA, Tunin C, Chang HC, Kan JS, Rowe PC: Provocation of hypotension and pain during upright tilt table testing in adults with fibromyalgia. Clin Exp Rheumatol 1997 May-Jun;15(3):239-46.
  
  

Ehlers-Danlos Syndrome

• Rowe PC, Barron DF, Calkins H, Maumenee IH, Tong PY, Geraghty MT: Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome. The Journal of Pediatrics . October 1999; 135(4). Review.